Titlebook: Clinical Trials In Parkinson‘s Disease; Santiago Perez-Lloret Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2021

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Assessment of Nonmotor Symptoms in Rodent Models of Parkinson’s Disease (PD) neuropathology and to develop new therapeutic strategies. The toxin-based rodent models of PD offer a valuable tool as they allow to mimic many of the features of the disease, particularly motor symptoms such as akinesia and bradykinesia. Interestingly, PD nonmotor symptoms, such as neuropsych

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Genetic Models of Parkinson’s Disease The etiology of idiopathic PD, which represents most of the cases, is still unclear but seems to be multifactorial, associating environmental and/or genetic factors. The major limitation of “classical” toxin-based animal models of PD?is that they?do not replicate some characterizing features of the

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Clinical Trials for Disease-Modifying Agents in Parkinson’s Diseaseor this. PD is clinically and pathophysiologically heterogeneous and has relatively insidious and protracted progression. Symptomatic therapies confound measurement of the disease as well. With this complexity comes the challenge of identifying optimal study design and outcome measures for clinical

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Value and Methods of Pharmacovigilance in the Monitoring of Drug Safety in Parkinson’s Diseases a key role in evaluating drug safety and efficacy under real-world conditions of use following market authorization. Pharmacovigilance focuses mainly on adverse drug reactions (ADRs), which are unintended adverse medical events caused by an approved drug used at normal human doses for the prophyla

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