Titlebook: Clinical Pharmacology of Learning and Memory; Walter B. Essman Book 1983 Spectrum Publications, Inc. 1983 pharmacology

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elastic

Macromolecules in Learning and Memory,puts to the central nervous system alter the ionic equilibrium of the cell cytoplasm and modify the stability of the nitrogenous bases of the RNA molecule (Hydén, 1959). Altered molecular structure through base modification leads to the synthesis of new RNA-dependent proteins capable of interacting

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TOXIN

Serotonin in Learning and Memory,mine and in amnesic agents or events, but also from pharmacological studies. An early study (Woolley, 1965) found that mice with an elevated brain serotonin level produced with a combination of 5-hydroxytryptophan (60 mg/kg) and benzlmethoxytryptamine (15 mg/kg) had a 13% reduction in the average nu

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一瞥

Barbiturates and Sedatives,anges in brain biogenic amines to changes in learning and memory. These classes of drug include the barbiturates and the benzodiazepines. The effects of representative agents upon the regional turnover of serotonin have been studied, and a generalized decrease was observed (Lidbrink et al., 1974). S

一瞥

Mood Alterants,n may also be given to agents that have been employed clinically as mood stabilizers. Among these are the tricyclic compounds commonly utilized for the treatment of depression. It may be recalled, as mentioned earlier, that at least one biochemical effect of agents in this class is to impair the nor

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Stimulants,le, interruption of the ascending serotonin ergic pathways in the rat with lesions of the medial forebrain bundle, leading to a 60–84% decrease in telencephalic serotonin, produced a threefold enhancement of amphetamine effect (Green and Harvey, 1974). An increased rate of operant conditioning respo