Titlebook: Clinical Pharmacology in Psychiatry; Strategies in Psycho Lars F. Gram,Luc P. Balant,Svein G. Dahl Conference proceedings 1993 Springer-Ver

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Molecular Modeling of Neurotransmitter Receptors and Ligands,ural information which may be potentially useful in drug development. X-ray crystallographic diffraction techniques are the most widely used experimental methods for determining three-dimensional protein structures. However, while the amino acid sequences are known for a continuously increasing numb

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,Structure-Function Analysis of the Three β-Adrenergic Catecholamine Receptors,genes, two of which (β. and β.) are devoid of introns, have been isolated and sequenced. Structurally, the β-AR proteins display the typical hallmarks of all the other membrane R7G receptors coupled to GTP binding proteins, as represented in Fig. 1. They consist of: (a) a single polypeptide chain, 3

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Relevance of 5-HT Autoreceptors for Psychotropic Drug Action,n. Accordingly, drugs influencing this system either have been found to be of therapeutic value in these disorders or they are developed systematically as new classes of psychotropic agents. Evidence for the heterogeneity of serotonin (5-hydroxytryptamine; 5-HT) receptors and recent progress in thei

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Serotonin Receptors and Antipsychotic Drug Action,y, 5-HT has an inhibitory effect on dopaminergic output (see Meltzer and Nash 1991, for review). However, there is also evidence that 5-HT can enhance some aspects of dopaminergic function; thus, an over-simplistic one-way model should not be considered (Meltzer and Nash 1991). The effect of 5-HT in

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