Titlebook: Clinical Management of Acute Lymphoblastic Leukemia; From Bench to Bedsid Mark R. Litzow,Elizabeth A. Raetz Book 2022 Springer Nature Switz

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,Régression sur variables qualitatives,MAPK, and PI3K signaling. In addition, aberrant expression of oncogenic transcription factors such as TAL1, LMO2, TLX1, and TLX3 and mutations in transcription factor tumor suppressors and epigenetic regulators result in altered differentiation and increased self-renewal.

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Book 2022 behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines cur

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https://doi.org/10.1007/978-2-287-39693-9nequivocal prognostic value of MRD in ALL, several outstanding issues need to be addressed, such as optimal methods of MRD detection and monitoring, timing for MRD assessment, and interlaboratory standardization and implementation, to further improve MRD-based risk stratification and intervention.

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Acute Lymphoblastic Leukemia in Infants: A Distinctive, High-Risk Subtype of Childhood Acute Lymphobels and early phase studies. In this chapter, we discuss the unique biological features of ALL in infants, provide a historical overview of the clinical trials and outcomes for infants with ALL, and offer insight into the novel treatment approaches in development.

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