Titlebook: Clinical Aspects of Blood Viscosity and Cell Deformability; G. D. O. Lowe (Lecturer in Medicine and Honorary S Conference proceedings 1981

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Erythrocyte Flexibility and Whole-blood Viscosityed blood cells and the plasma viscosity are the main factors which determine the viscosity of blood at high shear rates, though quantitative evidence for this hypothesis is lacking in the range of viscosity between these two extremes.

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Measurement of Whole-blood Viscosityy measurements would have to be carried out at a range of constant definable shear rates (Hess, 1915). The clinical interest in haemorheology therefore ceased until such measurements became possible with the advent of rotational viscometers in the 1960s.

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Relationship of Blood Rheology to Blood Flownt that Poiseuille’s law is a reasonable approximation in these circumstances it is clear that a reduction in the viscosity of blood would increase mean velocity in the arteries, and this would be a logical way of improving an ailing circulation.

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,Motoring’s Bicycling Beginnings,has led to a growing interest in the assessment or measurement of red-cell deformability. There are, however, a multiplicity of techniques in use, and the relationship between them and the parameters they measure is often unclear.

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,Stegmüller on Kuhn and Incommensurability,odynamics. It is therefore not surprising that the reaction of the general biomedical public is one of neglect or of almost emotional rejection — as evidenced in a recent editorial in an influential journal (Anonymous, 1977), in which the biological significance of the shear-rate dependence of apparent blood viscosity was totally denied.

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Conference proceedings 1981umented many of the techniques, and the basic scientific and clinical observations, which have helped to open up understanding of this highly important aspect of human physiology and pathology in recent years. The text is logically divided into five sections beginning with blood cell deformability,

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hich they point out that whereas human erythrocytes at rest have a diameter of approxi- mately 7. 5 /-tm, nutritive capillaries have diameters ranging from 3-5 /-tm, and chapters in section A give an account of the ways in which the red cell can undergo deformation to permit capillary perfusion and the mainte978-1-4471-3107-6978-1-4471-3105-2