Titlebook: Circulating Tumor Cells; Richard J. Cote,Ram H. Datar Book 20161st edition Springer Science+Business Media, LLC, part of Springer Nature 2

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Regulation of the Pharmaceutical Industrye as groundwork for future efforts in discovery and development of novel CTC-based genomic biomarkers. Further molecular profiling of CTCs may provide novel insights into mechanisms of disease progression and tumor evolution, and open new avenues for personalized treatment.

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Book 20161st editionhe basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers..CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of addi

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Significance of Studying Circulating Tumor Cellsxtensively studied only in the last decade or so. Understanding the biological and clinical impact of CTC is likely to reveal important information of the metastatic process and contribute to better management of cancer. We briefly discuss here the current clinical utility of CTC and their emerging

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Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Chaancer management (Cristofanilli et al., N Engl J Med 351(8):781–791, 2004; Cohen et al., J Clin Oncol 26(19):3213–3221, 2008; de Bono et al., Clin Cancer Res, 14(19):6302–6309, 2008; Poveda et al., Gynecol Oncol, 122(3):567–572, 2011). However, the technical hurdle for studying CTCs is their rare pr

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Cancer Stem Cells and Circulating Tumor Cells: Molecular Markers, Isolation Techniques, and Clinicalls” (CSCs). These cells have the ability to self-renew and to generate heterogeneous populations that constitute the tumor bulk. Preclinical studies have demonstrated that CSCs mediate tumor metastasis and resistance to chemotherapy and radiation therapy. CSC biomarkers have been identified and both