Titlebook: Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring; An Introduction Peter B. Gahan Book 2015 Springer Science

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Detection of Genetic Alterations by Nucleic Acid Analysis: Use of PCR and Mass Spectroscopy-Based Me fragments can be too low for accurate measurements with other spectrophotometric methods. However, the accuracy, the high through-put and multiplexing capabilities of mass spectrometry becomes an interesting tool for the quantification as well as for the characterization of circulating DNA.

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Genomic Approaches to the Analysis of Cell Free Nucleic Acidscopy number variation and point mutation from cell-free DNA. We also review recent clinical applications of sequencing cell-free DNA, from the non-invasive diagnosis of fetal genetic defects, to detection of tumor mutations from plasma and monitoring rejection of organ transplantation. In addition,

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The Biology of CNAPSA/RNA present together with the variables affecting these amounts, (c) possible sources of the DNA/RNA in blood and (d) the ability of the circulating nucleic acids to enter other cells and to modify the biology of the recipient cells. The relationship of the DNA from cancer patients is considered with respect to the formation of metastases.