Titlebook: Chromosomes Today; Volume 12 N. Henriques-Gil,J. S. Parker (Professor of Plant Book 1997 Springer Science+Business Media Dordrecht 1997 Ch

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Characterization of amplified DNA sequences in human cancers resistance in cultured cell lines, it also occurs during tumourigenesis, more frequently in solid tumours than in hemopoietic malignancies (for review, Alitalo and Schwab, 1986; Schwab and Amler, 1990). Two types of chromosomal structures, the homogeneously staining regions (hsr) and double minute

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The replication of ribosomal RNA genes in eukaryoteswhen a cell is going to divide. However, entry into mitosis depends upon the successful termination of DNA replication. Initiation and termination of DNA replication are two relevant events for dividing cells.

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Genomic interactions: gene expression, DNA methylation and nuclear architecturematin from related species into cultivated crops. Genetic engineering and hybridization techniques permit assembly in a single organism of the advantages of different organisms; however, in many cases the regular expression of the inserted genes cannot be ensured. Thus, integrated in a context of ge

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Chromosome behaviour in earliest meiotic prophase) during meiotic prophase I. This ensures the faithful segregation of homologues at Metaphase I. Chromatids are separated at metaphase II (Hawley, 1988). At the onset of prophase I, sister chromatids of meiotic chromosomes become connected by axial elements (cores) which run along their entire lengt

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Cytogenetics: yesterday, today and forever. A conceptual and historical viewhat the birth of Genetics lasted for eighty years: it started in 1865(66) when Mendel published his experimental results and finished in 1944 when Avery, McLeod and McCarty identified Griffith’s transforming principle.

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Chromosome differentiation using nucleases: an overviewize GC- or AT-enriched DNA motifs, physicochemical modifications of the chromatin, and the incorporation of modern molecular techniques into cytogenetics would prove to be the first steps along new pathways in the production of longitudinal differentiation of metaphase chromosomes or interphase nucl

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Genes controlling chromosome structure in , ‘scaffold’ of nonhistone proteins (Marsden and Laemmli, 1979). This scaffold is thought to contain a loose network of discrete anchoring complexes which, upon histone depletion and fixation, may collapse into a continuous proteinaceous structure (for reviews see Paulson, 1988; Gasser .., 1989).