Titlebook: Chromosome Translocation; Yu Zhang Book 2018 Springer Nature Singapore Pte Ltd. 2018 Cancer.Chromosome Translocation.DNA repair.Genome Org

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Dynamics of Double-Strand Breaks: Implications for the Formation of Chromosome Translocations,ten plays key roles in tumorigenesis. Emerging evidence suggests that the mobility of broken DNA loci can be an important determinant in partner search and clustering of individual breaks, events that can influence translocation frequency. We summarize here the recent literature on the mechanisms th

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The CRISPR/Cas9 System as a Tool to Engineer Chromosomal Translocation In Vivo,gineering small and large portions of chromosomes to induce a variety of structural alterations such as deletions, inversions, insertions and inter-chromosomal translocations. Furthermore, the availability of viral vectors that express Cas9 has been critical to deliver the CRISPR/Cas9 system directl

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Generation of Genomic Alteration from Cytidine Deamination,d lymphomas, the collateral effect of programmed DNA alterations during immune diversification is the major source of genome instability. Cytidine deamination from cytidine (C) to uridine (U) at immunoglobulin (Ig) gene loci is required for initiation of antibody diversification, while the same proc

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The Role for the DSB Response Pathway in Regulating Chromosome Translocations,ction, signaling and repair. Central to this network is the ATM kinase and its substrates at chromatin surrounding DSBs H2AX, MDC1 and 53BP1. In humans, germline inactivation of ATM causes Ataxia Telangiectasia (A-T), an autosomal recessive syndrome of increased proneness to hematological malignanci