Titlebook: Chromosomal Translocations and Genome Rearrangements in Cancer; Janet D. Rowley,Michelle M. Le Beau,Terence H. Rab Book 2015 Springer Inte

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Molecular Genetics Methods in Discovery of Chromosome Structurerom single nucleotide changes to those involving parts of chromosomes or whole chromosomes, likely reflect the many different solutions taken by individual tumours to escape normal growth regulatory mechanisms. A variety of molecular and cytogenetic techniques, differing in resolution and capabiliti

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Mechanisms of Recurrent Chromosomal Translocationsrrent chromosomal translocations are found in various cancers. Recently developed high-throughput approaches to clone genome-wide translocations that involve site-specific DSBs have provided new insights into mechanisms of chromosomal translocations. Such studies confirmed that, beyond cellular sele

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Immunoglobulin and , Rearrangements in Multiple Myeloma Pathogenesisined significance. Both are characterized by hyperdiploidy and recurrent immunoglobulin gene translocations that all result in the direct or indirect dysregulation of the CCND/RB1 pathway. Analysis of the translocation breakpoints suggests that they most frequently occur as a result of an error duri

cyanosis

Chromosomal Translocations in B Cell Lymphomasnant transformation of mature B cells, most commonly at the germinal centre (GC) stage of differentiation. Analogous to most cancer types, these tumours are caused by alterations of oncogenes and tumour suppressor genes, some of which have specific roles in GC development. This chapter will focus on

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Chromosomal Translocations and Gene Rearrangements in Acute Lymphoblastic Leukaemia lymphoid blast cells resembling early B- or T-cell progenitors. ALL occurs as a result of genetic, epigenetic and chromosomal aberrations that lead to unregulated cellular proliferation, a block in lymphocyte differentiation, aberrant cell survival and enhanced self-renewal. Chromosomal lesions can