Titlebook: Chromosomal Instability in Cancer Cells; B. Michael Ghadimi,Thomas Ried Book 2015 Springer International Publishing Switzerland 2015 Aneup

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Book 2015f strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for th

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https://doi.org/10.1007/978-3-658-03994-3 and to the initiation of tumors, however, initiated tumors need to reactivate telomerase in order to stabilize chromosomes and to gain immortal growth capacity. In this review, we summarize current knowledge on the role of telomeres in the maintenance of chromosomal stability and carcinogenesis.

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Auftrittswirkung im Corporate Speakingecular characterization of cytogenetic abnormalities has provided insights into the mechanisms of tumorigenesis and has, in a few instances, led to the clinical implementation of effective diagnostic and prognostic tools, as well as treatment strategies that target a specific genetic abnormality.

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über Wirkung und Wert von Rhetorikand physiology. This chapter focuses on the current understanding of how the yeast . . responds to the acquisition of extra chromosomes and highlights how studies in aneuploid yeasts provide insights onto the effects of aneuploidy in human cells.

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