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Titlebook: Chromosomal Instability in Cancer Cells; B. Michael Ghadimi,Thomas Ried Book 2015 Springer International Publishing Switzerland 2015 Aneup

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發(fā)表于 2025-3-21 18:27:11 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Chromosomal Instability in Cancer Cells
編輯B. Michael Ghadimi,Thomas Ried
視頻videohttp://file.papertrans.cn/227/226332/226332.mp4
概述Reviews up-to-date knowledge of chromosomal instability in cancer.Examines strategies to harness this information for the better treatment of cancer patients.Written by acknowledged experts in the fie
叢書名稱Recent Results in Cancer Research
圖書封面Titlebook: Chromosomal Instability in Cancer Cells;  B. Michael Ghadimi,Thomas Ried Book 2015 Springer International Publishing Switzerland 2015 Aneup
描述.This issue of .Recent Results in Cancer Research. presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification..
出版日期Book 2015
關(guān)鍵詞Aneuploidy; Cancer; DNA Repair; Disease Outcome; Genomic Instability
版次1
doihttps://doi.org/10.1007/978-3-319-20291-4
isbn_softcover978-3-319-34962-6
isbn_ebook978-3-319-20291-4Series ISSN 0080-0015 Series E-ISSN 2197-6767
issn_series 0080-0015
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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Recent Results in Cancer Researchhttp://image.papertrans.cn/c/image/226332.jpg
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https://doi.org/10.1007/978-3-319-20291-4Aneuploidy; Cancer; DNA Repair; Disease Outcome; Genomic Instability
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978-3-319-34962-6Springer International Publishing Switzerland 2015
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https://doi.org/10.1007/978-3-658-03994-3hromosomal instability. Telomeres are composed of repetitive DNA sequences (TTAGGG)n in humans, that are bound by specialized telomere binding proteins. Telomeres lose capping function in response to telomere shortening, which occurs during each division of cells that lack telomerase activity—the en
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über Wirkung und Wert von Rhetorik consequence of an increased rate of whole chromosome missegregation during mitosis, a process known as chromosomal instability (CIN). In fact, CIN is a hallmark of human cancer and is thought to contribute to tumorigenesis, tumor progression, and the development of therapy resistance by providing a
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