| 書目名稱 | Chemogenomics and Chemical Genetics | | 副標(biāo)題 | A User‘s Introductio | | 編輯 | ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère | | 視頻video | http://file.papertrans.cn/225/224900/224900.mp4 | | 概述 | Conceived for beginners.Not only for medicinal chemists, but any biologist, chemist, mathematician or IT scientist interested in that field.Written by experts from both the academic (University) and p | | 圖書封面 |  | | 描述 | .Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage an | | 出版日期 | Book 2011 | | 關(guān)鍵詞 | Bioactivity; Chemical genetics; Chemogenomics; Diversity-oriented synthesis; High-content screening; Mole | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-19615-7 | | isbn_softcover | 978-3-662-51991-2 | | isbn_ebook | 978-3-642-19615-7 | | copyright | Springer-Verlag Berlin Heidelberg 2011 |
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