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Titlebook: Chemical Mutagens; Principles and Metho Alexander Hollaender Book 1971 Springer Science+Business Media New York 1971 Allele.DNA.Fixation.Ha

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發(fā)表于 2025-3-21 18:06:51 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Chemical Mutagens
副標(biāo)題Principles and Metho
編輯Alexander Hollaender
視頻videohttp://file.papertrans.cn/225/224373/224373.mp4
圖書封面Titlebook: Chemical Mutagens; Principles and Metho Alexander Hollaender Book 1971 Springer Science+Business Media New York 1971 Allele.DNA.Fixation.Ha
描述The best protection against environmental mutagens is to identify them before they ever come into general use. But it is always possible that some substance will escape detection and affect a large number of persons without this being realized until later generations. This article considers ways in which such a genetic emergency might be promptly detected. A mutation-detecting system should be relevant in that it tests for effects that are as closely related as possible to those that are feared. It should be sensitive enough to detect a moderate increase in mutation rate, able to discover the increase promptly before more damage is done, responsive to various kinds of mutational events, and designed in such a way as to maxi- mize the probability that the Gause of an increase can be found. Methods based on germinal mutation necessarily involve enormous numbers of persons and tests. On the other hand, with somatic mutations the individual cell becomes the unit of measurement rather than the in- dividual person. For this reason, I think that somatic tests are preferable to germinal tests, despite the fact that it is germinal mutations which are feared.
出版日期Book 1971
關(guān)鍵詞Allele; DNA; Fixation; Hamster; Handling; Mamma; Salmonella; Termination; Tumor; chromosome; emergency; genes; h
版次1
doihttps://doi.org/10.1007/978-1-4615-8969-3
isbn_softcover978-1-4615-8971-6
isbn_ebook978-1-4615-8969-3
copyrightSpringer Science+Business Media New York 1971
The information of publication is updating

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Aspergillus,by Pontecorvo . (1953) partly because of its challenge as a homothallic filamentous fungus and partly because it seemed likely to have characteristics which would make it favorable for an approach to a variety of problems. Some of its merits, as they can be seen now, are the following: it grows on a
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Induction and Analysis of Gene Mutations in Mammalian Cells in Culture, cultures for genetic studies has long been recognized, substantial progress in this attempt was not made until the past 15 years, when improved and simplified techniques for cell culture became available. In particular, the plating technique for mammalian cells developed by Puck and associates (Puc
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Inducing Mutations with Chemicals in Habrobracon,anism in which dominant lethality can be unequivocally and easily distinguished from cell inactivation. Through production of haploid males from unfertilized eggs, the entire genome is available for analysis. Further, habrobracon has a short life cycle (6–14 days, depending on the species and the te
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Specific Locus Mutation in Mice,e made with the most confidence when they are derived from work with a mammal. The mouse is the mammal offering the most advantages for genetical studies since it is a small, rapidly breeding animal that can be kept in large numbers in a relatively limited amount of space. In addition, a great many
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