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Titlebook: Chemical Induction of Cancer; Modulation and Combi Joseph C. Arcos,Mary F. Argus,Yin-tak Woo Book 1995 Birkh?user Boston 1995 Alanin.Amino

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發(fā)表于 2025-3-21 18:18:11 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Chemical Induction of Cancer
副標題Modulation and Combi
編輯Joseph C. Arcos,Mary F. Argus,Yin-tak Woo
視頻videohttp://file.papertrans.cn/225/224346/224346.mp4
圖書封面Titlebook: Chemical Induction of Cancer; Modulation and Combi Joseph C. Arcos,Mary F. Argus,Yin-tak Woo Book 1995 Birkh?user Boston 1995 Alanin.Amino
描述In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic factors in the induction of cancer. The major emphasis has been on the discovery of many chemical carcinogens of widely different structures, their metabolism by various tissues and cells, and, in turn, their molecular-biochemical effects on the cells. This rapidly expanded body of information, as effectively covered in the predecessor volumes, is an excellent entree to the second half of the overall problem of chemical carcinogenesis, the processes. The active agents trigger a large array of molec
出版日期Book 1995
關鍵詞Alanin; Amino acid; Calcium; Colon; DNA; RNA; Vitamin D; aging; angiogenesis; apoptosis; classification; gene e
版次1
doihttps://doi.org/10.1007/978-1-4612-4076-1
isbn_softcover978-1-4612-8640-0
isbn_ebook978-1-4612-4076-1
copyrightBirkh?user Boston 1995
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發(fā)表于 2025-3-21 23:53:36 | 只看該作者
Intercellular Communication: A Paradigm for the Interpretation of the Initiation/Promotion/Progressi “The hopes … must be balanced against pessimism borne of two long-standing frustrations in oncogenetics: (a) the failure to identify the relevant targets for the neoplastic action of oncogenes, even when the oncoproteins have provocative biochemical properties, such as protein kinase or guanine nucleotide binding activity …”.
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Problems Involving Change of Typembinations of chemicals, (b) the lack of a universally accepted index for quantitative measurement of cancer risk of chemical carcinogens, and (c) the uncertainty of the possible outcomes of interactions among the various constituents of the mixture.
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Multifactor Interaction Network of Carcinogenesis — A “Tour Guide”) and of endocrine balance, and antagonists and/or synergists-are taken into account (.. 1). In addition, the majority of the factors that can modulate carcinogenesis directly and indirectly (Table 1) influence the effect of each other, so that the totality forms a complex, interwoven interaction network.
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發(fā)表于 2025-3-22 19:15:33 | 只看該作者
in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, loc
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發(fā)表于 2025-3-23 03:35:37 | 只看該作者
Synergism and Antagonism Between Chemical Carcinogensrcinogenicity in which relatively high doses of single agents have been used predominantly to establish the relative risk that chemical compounds may represent. This approach has been questioned for two reasons:
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