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Titlebook: Chemical Carcinogenesis; Models and Mechanism Francesco Feo,Paolo Pani,Renato Garcea Book 1988 Springer Science+Business Media New York 198

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書目名稱Chemical Carcinogenesis
副標(biāo)題Models and Mechanism
編輯Francesco Feo,Paolo Pani,Renato Garcea
視頻videohttp://file.papertrans.cn/225/224295/224295.mp4
圖書封面Titlebook: Chemical Carcinogenesis; Models and Mechanism Francesco Feo,Paolo Pani,Renato Garcea Book 1988 Springer Science+Business Media New York 198
描述About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino- genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
出版日期Book 1988
關(guān)鍵詞apoptosis; cancer; carcinogenesis; cell; cell culture; etiology; hormones; liver; liver tumor; mutagen; pathog
版次1
doihttps://doi.org/10.1007/978-1-4757-9640-7
isbn_softcover978-1-4757-9642-1
isbn_ebook978-1-4757-9640-7
copyrightSpringer Science+Business Media New York 1988
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VB 2008 Programming Constructs, Part I be present in the workplace, in cigarette smoke, synthetic fuels, and as pyrolysis products formed during the cooking of foods.; while nitroaromatic hydrocarbons have been used as dye intermediates, antimicrobial drugs, and food additives or have been detected as pollutants in coal fly ash, urban a
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Pro VB 2008 and the .NET 3.5 Platformne of the most widely studied carcinogenic hydrocarbons is benzo-(a)pyrene (BaP). Most pathways of BaP metabolism result in the production of metabolites that are detoxification products. However, a small proportion of the BaP metabolites are reactive derivatives that bind to DNA in cells and these
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VB 2008-Specific Language Featuresal and toxicological activity and, hence most important, potential population risk. They are probably the most ubiquitous in occurrence. A number of these, because of their use as pesticides and aerosol propellents and their high chemical stabilities, have become distributed throughout the biosphere
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