Titlebook: Chemical Biology; Methods and Protocol Jonathan E. Hempel,Charles H. Williams,Charles C. Book 2015 Springer Science+Business Media New Yor

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https://doi.org/10.1007/978-1-4302-1603-2ere, we describe methods used to develop high content screening assays implementing multipotent cardiovascular progenitors derived from human pluripotent stem cells and have identified novel compounds that direct cardiac differentiation.

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High Content Screening for Modulators of Cardiac Differentiation in Human Pluripotent Stem Cellsere, we describe methods used to develop high content screening assays implementing multipotent cardiovascular progenitors derived from human pluripotent stem cells and have identified novel compounds that direct cardiac differentiation.

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High Content Screening for Modulators of Cardiovascular or Global Developmental Pathways in Zebrafisssays, chemically targeting select pathways without causing pleiotropic effects. Here, we describe methods used to develop high content screening assays implementing transgenic zebrafish to assess phenotypic changes that have identified several classes of novel compounds that effect developmental pathways.

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Identification of Therapeutic Small-Molecule Leads in Cultured Cells Using Multiplexed Pathway Reporegies to single out reagents with sought-after cellular activities. In addition to representing high-priority therapeutic targets, intensely studied cell signaling systems encapsulate robust reference points for mapping novel chemical activities given our deep understanding of the molecular mechanis

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