Titlebook: Challenges and Opportunities of mRNA Vaccines Against SARS-CoV-2; A Multidisciplinary Siguna Mueller Book 2023 The Editor(s) (if applicabl

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mRNA Covid-19 Vaccines Best Reflect Effective Pharmaceuticals—Basic Considerations and LNPsonventional vaccines: (1) are preparations that have been made in order to meet the host immune system at a certain site of encounter (injection site); (2) involve a certain amount and type of immunologic agents; and (3) result in stimulation of immune responses to turn on immunologic memory. Accord

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Other Facets of SARS-CoV-2 Immunity, the Risk of Immune Tolerance and T Cell Exhaustionlen the limelight.” Especially during the first two years of the pandemic, the level of “neutralizing antibodies” was believed to be the main and key factor indicating protection. However, as seen from the course of the pandemic, antibody levels alone are not sufficient to prevent infection (Chap. .

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