| 書目名稱 | Cellular and Molecular Aspects of Ageing | | 編輯 | Valquiria Bueno | | 視頻video | http://file.papertrans.cn/224/223082/223082.mp4 | | 概述 | Focuses on health ageing.Provides a comprehensive discussion of the hallmarks of ageing.Discusses life style, possible therapies, and clinical trials | | 圖書封面 |  | | 描述 | .Even though life expectancy increased in the last decades, ageing has been considered a strong risk factor for age-related diseases, disability and death. The further understanding of cellular and molecular aspects of ageing could predict the onset of diseases in advance, prevent functional decline and identify targets for interventions focused in healthy ageing. .The hypothesis that organismal ageing and dysfunction is influenced by the accumulation of senescent cells had origin in Hayflick and Moorhead results from cultured human fibroblasts. It was shown that fibroblasts presented a limited capacity for proliferation reaching thus the state of irreversible growth arrest (replicative senescence). In 2011, van Deusen et al. showed that p16.Ink4a .accumulation was associated with premature ageing in a mouse model and the inactivation of the p16.Ink4a .gene mitigated the ageing phenotype. Thus, the cell cycle arrest due to the expression of p16.Ink4a?.and p21.CIP .(cell cycle inhibitors) is the main characteristic of senescence. In addition to cellular senescence, the hallmarks of ageing include genomic instability, telomere shortening , epigenetic alterations, loss of proteostasis | | 出版日期 | Book 2024 | | 關(guān)鍵詞 | Ageing; Longevity; Tissues; Cells; Molecules; Immune System | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-031-55022-5 | | isbn_softcover | 978-3-031-55024-9 | | isbn_ebook | 978-3-031-55022-5 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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