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Titlebook: Cellular and Molecular Alterations in the Failing Human Heart; G. Hasenfuss,Ch. Holubarsch,N. R. Alpert Conference proceedings 1992 Dr. Di

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書目名稱Cellular and Molecular Alterations in the Failing Human Heart
編輯G. Hasenfuss,Ch. Holubarsch,N. R. Alpert
視頻videohttp://file.papertrans.cn/224/223080/223080.mp4
圖書封面Titlebook: Cellular and Molecular Alterations in the Failing Human Heart;  G. Hasenfuss,Ch. Holubarsch,N. R. Alpert Conference proceedings 1992 Dr. Di
描述The myocardium in heart failure: Cellular and subcellular alterations in the failing human myocardium. H. Just Medizinische Universitatsklinik Freiburg i. Br., Innere Medizin III - Kardiologie, FRG The syndrome of heart failure continues to be a major challenge to clinicians and scientists. Incidence and mortality of the disease are high, the patient is disabled, and is permanently threatened by the high morbidity and mortality. The clinician faces a syndrome of complex pathophysiology. Multiple causes or underlying disorders of the heart have to be differentiated from heart failure itself, which often results in exceedingly difficult diagnoses. Likewise, prognostication meets with difficulties due to problems in separating influences of the underlying disease and the heart failure syndrome itself. In chronic refractory failure annual mortality may exceed 50%. If aortic stenosis or ischemic cardiomyopathy with main- stem lesions are present, this percentage may be even higher. The situation becomes particularly threatening to the patient when the reduction in cardiac performance goes along with complex ventricular arrhythmias. Therapy has remained difficult and of limited effective
出版日期Conference proceedings 1992
關鍵詞cardiovascular; cardiovascular function; heart; heart failure; heart muscle; metabolism; pathophysiology; p
版次1
doihttps://doi.org/10.1007/978-3-642-72474-9
isbn_softcover978-3-642-72476-3
isbn_ebook978-3-642-72474-9
copyrightDr. Dietrich Steinkopff Verlag GmbH & Co.KG, Darmstadt 1992
The information of publication is updating

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Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular funcdence for the role that these isozymes have in the regulation of cellular processes has been generated through, or awaits, the identification of selective and potent PDE inhibitors. While selective inhibitors of the cGMP-inhibitable (cGi)-PDE isozyme have been approved for use in the acute treatment
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Na,K-ATPase expression in normal and failing human left ventriclereparation for orthotopic transplantation or at the time of organ harvest. Abundance of mRNA for all three catalytic α subunits of the Na,K-ATPase was analyzed in samples from patients with end-stage heart failure due to either ischemic or dilated cardiomyopathy, as well as from normal controls. Van
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Structural and functional diversity of human ventricular myosinpressed, possible alterations in the myosin molecule could be of particular relevance. There is increasing evidence that myofibrillar ATPase activity is reduced in congestive heart failure, whereas the findings on myosin ATPase are still controversial. The molecular causes of the reduced activity ar
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