Titlebook: Cellular and Biomolecular Mechanics and Mechanobiology; Amit Gefen Book 2011 Springer-Verlag Berlin Heidelberg 2011 Biorheology.Cell defor

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Cytoskeletal Mechanics and Cellular Mechanotransduction: A Molecular Perspective,to capture the highly dynamic and constantly changing properties of the cells to external and internal stimuli. Finally, the concept of cellular mechanotransduction is discussed as an essential function of the cell wherein the cytoskeleton plays a key role.

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Forces During Cell Adhesion and Spreading: Implications for Cellular Homeostasis,ries of distinct phases, each with their own force signature. In addition, we consider how intracellular force affects mechanical cellular homeostasis and maintenance of tissue structure and function. The disruption of cellular mechanical homeostasis is described in the context of two prominent dise

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The Physical Mechanical Processes that Shape Tissues in the Early Embryo,re finding hints that mechanical processes may be playing novel roles in developing embryos in addition to their direct roles in shaping tissues. Many early molecular pathways regulating cell differentiation and embryonic morphogenesis are reused as tumors grow and metastasize and during the regener

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Mechanobiology of Primary Cilia,sting ciliary flow sensing mechanisms in kidney epithelial cells, cardiovascular endothelial cells, bile duct epithelial cells, nodal cells, and bone cells. We demonstrate that ciliary sensation of fluid flow can involve molecular mechanisms that are shared across diverse cell types, yet can also un

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Mechanics of Airway Smooth Muscle Cells and the Response to Stretch,m each stretch. Chronic stretching leads to further changes as contractile phenotype becomes altered. The response to stretch has become one of the most important characteristics of ASM mechanics and defines its function, and ultimately may underlie dysfunction in airway diseases such as asthma.

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Finite Element Modeling of Cellular Mechanics Experiments,. Its application has been rapidly growing over the last decade due to its ability to quantify deformations, strains and stresses in and around cells, thus providing basic understating of the mechanical state of cells and allowing identification of mechanical properties of cells and cellular organel

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Mechanobiology and Finite Element Analysis of Cellular Injury During Microbubble Flows,ment models that provided quantitative information about cellular deformation during microbubble flows. These models suggested several pharmaco-protective strategies for reducing epithelial cell (EpC) injury by altering cell mechanics and these predictions were confirmed by a new set of clinically r