Titlebook: Cellular Peptidases in Immune Functions and Diseases 2; Jürgen Langner,Siegfried Ansorge Book 2002 The Editor(s) (if applicable) and The A

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A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidese IV (DP IV/CDthe catalytic site of DP IV. The compounds are characterized as sensitive substrates of cell surface associated DP IV of DP IV rich U-937 cells. The binding of the enzymatically released R110-Y on cells results in a stable cellular fluorescence. This way, the quantitative determination of cell surface associated DP IV activity is possible.

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Modulation of WNT-5At Eexpression by Actinonin: Linkage of APN to the WNT-Pathway?g theseeffects are not known as yet. Applying the cDNA array technique we identified the proto-oncogen Wnt-5a strongly affected by APN-inhibition Wnt-5a and other members of the Wnt family of secreted factors are implicated in cell growth and differentiation. Wnt-5a was moderately expressed in resti

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Transforming Growth Factor-β Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Mcells and during most developmental stages of myeloid cells. Because APN/CD13 has been implicated in the trimming on the cell surface of peptides that protrude out of MHC class II molecules, we wanted to study the regulation of this membrane peptidase in antigen presenting cells by TGF-β, TGF-β is a

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Natural Substrates of Dipeptidyl Peptidase IVion and physiological circumstances. It is at present impossible to depict a certain chain length as the maximal acceptable substrate size as it turns out that the immediate surrounding and surface accessibility of the NH.-terminal dipeptide are determining the susceptibility for cleavage of a pepti

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A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidese IV (DP IV/CDtion of fluorophores. Rhodamine 110 (Rl10), a highly fluorescent Athene dye, was used to synthesize nonfluorescent dipeptidyl peptidase IV (DP IV) substrates Xaa-Pro-R110-Y allowing the stable covalent binding of the enzymatically released fluorescent R110- on cells. All compounds have been characte

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