Titlebook: Cell and Molecular Biology of the Cytoskeleton; Jerry W. Shay Book 1986 Plenum Press, New York 1986 DNA.Organe.Organelle.Translation.cell

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The Structure and Evolution of Intermediate Filament Genes,d into at least five distinct subclasses, each of which contains from 1 to 30 subunits encoded by separate genes (Lazarides, 1980; Fuchs and Hanakoglu, 1983). These genes are differentially expressed in different tissues and during different stages of differentiation (Lazarides, 1980; Steinert .., 1

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Differential Expression of the Genes Encoding the Keratins of Cultured Human Epidermal Cells,Under an as yet unidentified trigger of differentiation, a basal cell will cease to divide, and subsequently, it begins to migrate toward the skin surface. The cells enter the spinous layer and increase steadily in size (Rowden, 1975; Yardley and Goldstein, 1976) as they continue to be active biosyn

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Organization and Expression of the Vimentin and Desmin Genes,n general morphology and diameter, in addition to the susceptibility to certain drugs, have been used to classify the observed cytoskeletal filaments. Actin filaments (6 nm in diameter), microtubules (25 nm) in nonmuscle cells, and myosin filaments (15 nm) in muscle cells were readily characterized.

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Actin,maintain cell shape and allow movement. This chapter provides evidence that actin is not constitutively expressed, but is tightly regulated. It also presents a speculative discussion, based on current research, which argues that actin is a regulator of cell growth and differentiation. This regulatio

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Implications of Microtubule Polarity for Microtubule Function,larity is believed to be important for many cellular activities. For example, the interaction of actin and myosin that produces shortening of the sarcomere in striated muscle depends on the correct vectorial orientation of actin filaments relative to myosin. While a convenient polarity marker for ac

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Regulation of Tubulin Expression in Brain,, in the determination of cell shape, and in neuronal growth and migration. In the mature nervous system, microtubules are also involved in synaptogenesis and in axonal transport (Olmsted and Borisy, 1973; Dustin, 1978).

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