Titlebook: Cell Transplantation for Neurological Disorders; Toward Reconstructio Thomas B. Freeman,H?kan Widner Book 1998 Springer Science+Business Me

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Transplantation Strategies for the Treatment of Pain,t the problem is far from being resolved with currently available therapeutic regimens. Numerous neurosurgical, physiological, psychological, and pharmacologic approaches have been attempted ., often with conflicting or disappointing outcomes in the long run. It has been estimated that 80% of all pa

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Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells, and development of effective, novel treatments is more efficient (i.e., faster and less costly) if those efforts are guided by a rational plan of action, based on careful consideration of the available data. Although tremendous technical and conceptual advances have been made in the neurosciences a

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Transplant Strategies in Myelin Disorders,elopmental disorders are major problems in human neurology. Multiple sclerosis (MS) is by far the most common acquired demyelinating disease, and in chronic MS, the failure of repair results in marked debilitation and morbidity. Severe debility is also seen in Pelizaeus-Merzbacher disease (PMD), a r

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Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases,degenerative diseases. The application of this hybrid technique is made possible by recent developments in several areas of biomedical research. Progress in molecular biology has led to the identification of an increasing number of genes involved in human disease. Developments in cell biology allow

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,The Lund Transplant Program for Parkinson’s Disease and Patients with MPTP-Induced Parkinsonism,m the grafts. These observations were taken further and applied in the Ungerstedt unilateral 6-OHDA-treated rat model of parkinsonism ., an animal model of dopamine depletion. In 1979, two groups demonstrated that embryonic dopaminergic neural tissue, obtained from the ventral mesencphalic region of

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,Neuropathology of Dopaminergic Transplants in Patients with Parkinson’s Disease, motor and nonmotor symptoms emerge that are not responsive to .-DOPA. Since treated patients show a life expectancy similar to that seen in age-matched controls, patients can survive with crippling symptoms for many years. Thus, new innovative treatment strategies are needed to sustain the quality

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Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases, great potential for the treatment of neurodegenerative diseases because current treatments are inadequate or not available. This chapter will focus on the development of somatic gene transfer and cell transplantation strategies for Parkinson’s disease (PD) but many of the principles outlined here a