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Titlebook: Cell Motility in Cancer Invasion and Metastasis; Alan Wells Book 2006 Springer Science+Business Media B.V. 2006 biology.carcinoma.imaging.

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書目名稱Cell Motility in Cancer Invasion and Metastasis
編輯Alan Wells
視頻videohttp://file.papertrans.cn/223/222854/222854.mp4
概述Ex vivo and in vitro model systems.In-depth discussion of four increasing tumor types.Five key signaling pathways that can be targeted.Includes new and emerging concepts and technologies
叢書名稱Cancer Metastasis - Biology and Treatment
圖書封面Titlebook: Cell Motility in Cancer Invasion and Metastasis;  Alan Wells Book 2006 Springer Science+Business Media B.V. 2006 biology.carcinoma.imaging.
描述.Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis..
出版日期Book 2006
關鍵詞biology; carcinoma; imaging; morbidity; tumorigenesis
版次1
doihttps://doi.org/10.1007/b103440
isbn_softcover978-90-481-7011-1
isbn_ebook978-1-4020-4009-2Series ISSN 1568-2102 Series E-ISSN 2215-1648
issn_series 1568-2102
copyrightSpringer Science+Business Media B.V. 2006
The information of publication is updating

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Matrices for Studying Tumor Cell Invasion,r cells is largely dependent on their ability to degrade and migrate through extracellular matrix (ECM) barriers, inhibition of its subroutines (proteolysis, ECM degradation, chemotaxis, haptotaxis etc.) become logical targets for experimental cancer therapy. To explore potential approaches to inhib
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Imaging Invasion and Metastasis , ,is. These results indicate that tumor cells can collaborate with macrophages during invasion. Such paracrine interactions between epithelial cells and macrophages likely reflect interactions that occur during ductal outgrowth in normal mammary gland development. The combination of . imaging with gen
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,Dynamic Functions of the α6β4 Integrin in Carcinoma,at could contribute to the remodeling of basement membranes during tumor invasion. Importantly, this altered localization of α6β4 appears to be coupled to an activation of its signaling potential. The primal signaling event triggered by α6β4 appears to be activation of PI3-K. Although the mechanism
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