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Titlebook: Cell Migration in Inflammation and Immunity; Methods and Protocol Daniele D’Ambrosio,Francesco Sinigaglia Book 2003 Humana Press 2003

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書目名稱Cell Migration in Inflammation and Immunity
副標(biāo)題Methods and Protocol
編輯Daniele D’Ambrosio,Francesco Sinigaglia
視頻videohttp://file.papertrans.cn/223/222849/222849.mp4
概述Includes supplementary material:
叢書名稱Methods in Molecular Biology
圖書封面Titlebook: Cell Migration in Inflammation and Immunity; Methods and Protocol Daniele D’Ambrosio,Francesco Sinigaglia Book 2003 Humana Press 2003
描述Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of leukocyte trafficking in basal and inflammatory conditions to the regulation of hema- poiesis, angiogenesis, tissue architecture, and organogenesis. The basis for such diversified activities rests, on one hand, upon the ubiquitous nature of chemokine production and chemokine receptor expression. Virtually every cell type can produce chemokines and expresses a unique combination of chemokine receptors. On the other hand, chemokine receptors make use of a flexible and complex network of intracellular signaling machineries that can regulate a variety of cellular functions ranging from cell migrat
出版日期Book 2003
版次1
doihttps://doi.org/10.1385/1592594352
isbn_softcover978-1-61737-357-2
isbn_ebook978-1-59259-435-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 2003
The information of publication is updating

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Analysis of Integrin-Dependent Rapid Adhesion Under Laminar-Flow Conditions,n the vessels, the blood flow imposes peculiar conditions by generating a wall shear stress that opposes leukocyte stable arrest on the endothelium. As the rapidness of integrin activation is mandatory to leukocyte adhesion to the blood vessels, any analysis of adhesion triggering relevant to leukoc
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Posttranslational Processing of Chemokines,ecific leukocyte subclasses. In vivo, leukocyte migration requires a network of molecules, including cytokines, chemokines, leukocyte adhesion molecules such as selectins and integrins, and proteases (.–.). This complex network provides different levels of specificity based on ligand-receptor intera
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Conditional Transgenic Models to Study Chemokine Biology,he elucidation of the mechanisms responsible for leukocyte recruitment is critical for the development of novel therapeutic approaches for these conditions. Among the molecules implicated in regulating leukocyte trafficking are the chemokines, low-molecular-weight secreted molecules that interact wi
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Intravital Microscopy as a Tool for Studying Recruitment and Chemotaxis,ocyte and endothelial cells. First, leukocytes in the mainstream of blood flow come into contact with the endothelium and they roll along the endothelial surface via a group of molecules termed the selectins (.). Next, rolling leukocytes are activated by pro-inflammatory molecules presented on the e
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