Titlebook: Cell Division Machinery and Disease; Monica Gotta,Patrick Meraldi Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusi

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The Elephant in the Room: The Role of Microtubules in Cancer,s cellular motility, cytoplasmic transport and cell division. Some the most effective chemotherapeutics, such as the taxanes, are microtubule interfering drugs. Moreover, many studies suggest that microtubule dynamics are altered in cancer cell divisions and linked to chromosomal instability, aneupl

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Clinical Development of Anti-mitotic Drugs in Cancer,get for anticancer therapies since fast proliferation was identified as one of the hallmarks of cancer cells. Despite efforts into developing specific inhibitors for mitotic kinases and kinesins, very few drugs have shown the efficiency of microtubule targeting-agents in cancer cells with paclitaxel

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Unbalanced Growth, Senescence and Aging,icient cell material is available and affects the overall rate of cell proliferation. At a very fundamental level, cellular replicative lifespan—defined as the number of times a cell can divide, is a manifestation of cell cycle control. Hence, control of mitotic cell divisions, especially when the c

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