Titlebook: Cell Culture in Pharmaceutical Research; N. E. Fusenig,H. Graf Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Pharmace

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0947-6075 nderstanding of the signaling mechanisms by which cells communicate in vivo and in vitro and modify adaptively. By using cell culture models in addition to animal experiments we are now able to better define the overall and the selective potential of drugs. This book is designed to give information

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F. Lippmann,C. Hofstede de Grootcolony-stimulating factors [CSF; macrophage CSF (M-CSF), granulocyte-macrophage CSF (GM-CSF)] or interleukin-3 (IL-3; multi-CSF) regulate the differentiation of this stem cell into monoblasts which then differentiate into promonocytes (Metcalf 1991).

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Differentiation of Human Monocytes In Vitro: A Model of Macrophage Ontogeny,colony-stimulating factors [CSF; macrophage CSF (M-CSF), granulocyte-macrophage CSF (GM-CSF)] or interleukin-3 (IL-3; multi-CSF) regulate the differentiation of this stem cell into monoblasts which then differentiate into promonocytes (Metcalf 1991).

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The Origin of the Pfeiffer Effectct premalignant stages can be identified which subsequently develop into the final malignant tumor (Fearon and Vogelstein 1990). By genetic and molecular analysis different genetic changes can be identified leading to activation or inactivation of genes, and these alterations may be correlated to distinct stages in tumor progression.

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Conference proceedings 1994al experiments we are now able to better define the overall and the selective potential of drugs. This book is designed to give information on the advantages and limitations and on new aspects and the meaning of cell culture models in pharmaceutical research.