Titlebook: Cell Biology and Translational Medicine, Volume 16; Stem Cells in Tissue Kursad Turksen Book 2022 The Editor(s) (if applicable) and The Aut

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Identification of Small Molecules That Enhance the Expansion of Mesenchymal Stem Cells Originating increased the ratio of cells in the S-G2-M phase. Enhanced MSC expansion with SB203580 therapy was associated with the lower expression of CDKIs like p15, p18, p19, p21, p27, and p57. In conclusion, we have developed a new approach to facilitate the expansion of BM-MSCs. These results could enhance

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,Human-Induced Pluripotent Stem Cell–Based Models for Studying Sex-Specific Differences in Neurodegegene-corrected human iPSCs, from both sexes, can be utilized to generate neuronal and glial cell types affected by specific neurodegenerative diseases to study sex-specific differences in two-dimensional (2D) and three-dimensional (3D) human culture systems. Such relatively simple and well-controlle

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,Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell–Ba mice models for bridging the gap between current small rodent models and human clinical trials for allogeneic and autologous inducible pluripotent stem cell (iPSC)–based ITx while highlighting limitations and future directions.

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Mesenchymal Stem Cell Therapy for Osteoarthritis: Practice and Possible Promises,d in a broad range of pre-clinical OA animal models as well as clinical studies with the aim of cartilage repair which had not previously been achieved using classical treatments. Here, the brief scientific review of MSC role in the control of OA as well as the proposed mechanisms are discussed. We

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An Overview of Zebrafish Modeling Methods in Drug Discovery and Development,In this context, applying several various approaches such as using chemicals, pathogens, and genetic manipulation approaches allows zebrafish development into a preferable model that mimics some human disease pathophysiology. Thus, such modeling approaches not only can provide a framework for a comp

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Cellular Stress Responses in Oocytes: Molecular Changes and Clinical Implications,in light of our understanding of similar mechanisms in other cell types and the limited transcriptional activity in oocytes. More fundamental research is needed both at the transcriptomic and proteomic levels to further understand cell stress response mechanisms in oocytes and early developing embry

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Epithelial Stem Cells: Making, Shaping and Breaking the Niche,d loss. These stem cells have been studied extensively as signal-receiving cells, responding to cues from other cell types and mechanical stimuli that comprise the niche. However, studies from a wide range of systems have identified epithelial stem cells as major contributors to their own microenvir