Titlebook: Catalytic RNA; Fritz Eckstein,David M. J. Lilley Book 1997 Springer-Verlag Berlin Heidelberg 1997 AIDS.HIV.Nucleotide.RNA.biology.catalysi

syncope

Concepts in Computational Cognition,hocytes being most apparent. There is a high mortality rate (90–100% over 10 years) associated with the progression to AIDS, the pathogenesis being a very complex process encompassing initial infection, acute syndrome, clinical latency, and finally, clinical disease (Fig. 1; Ho et al. 1989; Pantaleo

Intellectual

Dynamics of a Group I Ribozyme Detected by Spectroscopic Methods,unction. The RNA motion most intensively studied thus far in this system is docking of substrate into the catalytic core of the ribozyme (Bevilacqua et al. 1992, 1993, 1994; Li et al. 1995; Li, Profenno and Turner, unpubl. results). This chapter reviews the methods and results of these studies, and

expeditious

Interaction of Aminoglycoside Antibiotics with RNA, weight products encompassing a wide range of different chemical classes from the secondary metabolism of microorganisms, able to inhibit growth of other microorganisms. Most of the effects on RNA function that were found are caused by aminoglycoside antibiotics — more specifically, by the disubstit

AWE

Structural Analysis of the Bacterial Ribonuclease P RNA,erstanding of the structure of the RNase P RNA. An important key to understanding the function and specificity of this interesting enzyme is to gain perspective on its structure. A detailed secondary structure model of the bacterial RNA has been derived through phylogenetic comparative analysis, and

cortex

Structural Analysis and Modifications of the Hairpin Ribozyme,ocessing site; it contains the sequences that are recognized by the ribozyme. Interestingly, the analogous RNA processing reactions that occur during replication of the plus strand utilize the hammerhead motif (Long and Uhlenbeck 1993). In contrast to phylogenetically abundant RNA catalysts such as

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intuition

Probing the Cleavage Activity of the Hammerhead Ribozyme Using Analog Complexes,metal cofactor in order to stabilize the transition state resulting along the cleavage pathway. Cleavage of the RNA occurs by an internal transesterification reaction involving the 2′-hydroxyl adjacent to the scissile phosphodiester, generating a terminal 5′-hydroxyl fragment and a terminal 2′,3′-cy

contrast-medium

Affiliation

Design, Synthesis, and Function of Therapeutic Hammerhead Ribozymes,ith protein enzymes has redefined the role that RNA may have played in early evolution (Cech 1993). Furthermore, these novel activities of RNA now permit us to contemplate the development of enzymatic RNA molecules as therapeutic entities for the treatment of human disease (Marschall et al. 1994; Ch

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