Titlebook: Cardiac Glycosides; Part I: Experimental Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 Drogen.Hormone.Lipid.Respi

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Optimality Conditions for Convex Problems,d to be inhibited by the cardiac glycosides (c.g.), k-strophanthoside, and digitoxin and their aglucons (., 1953). The drug concentrations necessary to yield this effect ranged from 0.1 μg/ml to 10μg/ml. This effect was shown to be due to an inhibition of membrane Na.-K.-ATPase activity (. et al., 1

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The Subdifferential of Convex Functionals,well known clinically that the therapeutic efficiency of these drugs is to a certain degree dependent on the metabolic state of the heart; they are most effective in hearts with no defects in energy metabolism such as congestive heart failure due to excessive hemodynamic pressure loads (e.g., hypert

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A Short Course in Control Theory,53; see . and ., 1959). Thus, with the discovery of Na ., K.-ATPase (., 1957; . and ., 1957), the effect of these glycosides on the enzyme activity was examined and a specific inhibition was observed (. et al., 1960; ., 1960; see Fig. 1). The interaction of cardiac glycosides with the enzyme, and it

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Generalized Gradients in Banach Space,er, generally accepted that their effects are directly on the cardiac cell (for reviews see . and ., 1971; . and ., 1979). A great variety of cellular and subcellular systems has been studied as putative primary points of interaction such as: polymerization of cardiac actin (. et al., 1949), myosin

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