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Titlebook: Cardiac Glycosides; Part II: Pharmacokin Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 absorption.kinetics.pharma

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書目名稱Cardiac Glycosides
副標題Part II: Pharmacokin
編輯Kurt Greeff (Direktor)
視頻videohttp://file.papertrans.cn/222/221778/221778.mp4
叢書名稱Handbook of Experimental Pharmacology
圖書封面Titlebook: Cardiac Glycosides; Part II: Pharmacokin Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 absorption.kinetics.pharma
描述The pharmacokinetics of digitalis glycosides have been the subject of extensive re- view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com- pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm- LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in- dicate that the elimination half-life of strophanthin is prolonged in renal failure.
出版日期Book 1981
關(guān)鍵詞absorption; kinetics; pharmacokinetics; research
版次1
doihttps://doi.org/10.1007/978-3-642-68166-0
isbn_softcover978-3-642-68168-4
isbn_ebook978-3-642-68166-0Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1981
The information of publication is updating

書目名稱Cardiac Glycosides影響因子(影響力)




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Against Recognising the Nonreligious,ng the xanthydrol or m-dinitrobenzol reaction (., 1958). Fluorescence techniques enabled additional inferences on the structure of the steroid nucleus to be obtained (., 1953; . et al., 1961; ., 1967). The main disadvantage of the foregoing methods is the relatively low sensitivity.
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https://doi.org/10.1007/978-3-658-10459-7same effect on the nonfailing heart, has only recently been recognized (. et al., 1961; . and ., 1963; . et al., 1966). Among the consequences of this new thinking is a change in attitudes to the indications for glycosides, as will be explained later.
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Cardiac Uptake and Binding of Cardiac Glycosidesus calculations, Clark showed that since it took 2 μg of ouabain to arrest a frog ventricle weighing 1 g and containing 3 × 10. cells, the lethal effect was due to the fixation of 10. ouabain molecules per cardiac cell. He also pointed out that the fixed ouabain molecules could not cover more than 3% of the surface of the cardiac cell.
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