Titlebook: Cardiac Energetics: From Emax to Pressure-Volume Area; Martin M. LeWinter (Professor of Medicine),Hiroyuk Book 1995 Kluwer Academic Publis

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Orthonormal Series and Approximation,, or contractile performance and energy demand, is mandatory. We have devoted ourselves to discovering a ventricular contractility index which is as much load independent as possible and to elucidating primary determinants of cardiac oxygen consumption with a sound physiological basis.

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Density Estimation for Small Samples,s characterized by an input-output relation. However, recent advances in biochemistry and molecular biology have revealed aspects of the internal structure of this black box at the molecular level (1). Often, however, the functional significance of these microscopic findings is not clear. In other w

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Orthonormal Series and Approximation,uired to do pressure-volume work (1,2). Using a plausible model of excitation contraction coupling and mechanoenergetics, Namba et al. (2) quantified the extent to which changes in the Ca.-affinity of troponin C (TnC), the Ca.-receptor activating myofilament activity, may affect the total amount of

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Orthonormal Series and Approximation,he E(t) function describes the time variations in instantaneous ventricular volume-elastance during a beat and was proposed as a load-independent characterization of dynamic ventricular pump properties. Additionally, the value of E(t) at end systole (E.), which is the slope of the end-systolic press

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Density Estimation for Small Samples,mputer designs offer performance that was in the realm of super computers only a decade ago. This allows chemistry and physics to be implemented in the mathematical modeling solution of biochemical problems. With sophisticated computer solutions available, various biochemical hypotheses can be quick

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https://doi.org/10.1007/978-1-4612-3686-3rly important since the mechanical work performed requires a high rate of energy consumption. In addition to routine needs for basal metabolism and maintenance of transmembrane gradients, cardiac tissue requires energy to support beat-to-beat cyclical calcium movement, and to allow contractile eleme

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How to Select the Smoothing Parameter?,on because of the nonuniform nature of contractile dysfunction in these patients. Also, patients with hypertrophic (1) or dilated cardiomyopathy (2) have been reported to demonstrate regional abnormalities in contraction. Global indexes of left ventricular function (for example, ejection fraction) c

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Vincent Blackburn,Shae Brennan,John Ruggieroology of ventricular fibrillation has attracted much interest not only from the viewpoint of basic electrophysiology, but also that of clinical cardiology. Despite the importance of this arrhythmia, little is known about the cellular metabolism of the heart when it is subjected to ventricular fibril

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Vincent Blackburn,Shae Brennan,John Ruggieroing (1–8). Both an increase in myofilament Ca. affinity and an increase in total systolic Ca. release have been identified as mechanisms of length-dependence of activation (1,3,5–7). With respect to energy consumption, only an increase in Ca. release would be anticipated to increase energy consumpti