Titlebook: Cardiac Drug Development Guide; Michael K. Pugsley Book 2003 Springer Science+Business Media New York 2003

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J. Brindley,A. V. Holden,A. PalmerMAPKs found in cardiac tissue include the extracellular signal-regulated kinases (ERKs), the stress-activated/c-Jun NH2-terminal kinases (SAPK/JNKs), p38-MAPK, and ERK5/big MAPK 1 (BMK1). The ERKs are strongly activated by mitogenic and growth factors and by physical stress, SAPK/JNKs and p38-MAPK c

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V. S. Letokhov,A. A. Makarov,E. A. Ryabov function, providing additional targets for drug development. However, clinical experience has shown that the therapeutic index for the existing potent platelet inhibitors is narrow, suggesting that new and novel approaches to impairing platelet function will be required.

photopsia

V. S. Letokhov,A. A. Makarov,E. A. Ryabovdominance of NHE-1 in the myocardium is of some importance because pharmacological development of NHE inhibitors for cardiac therapeutics has concentrated specifically on those agents that are selective for NHE-1. These agents, as well as the earlier nonspecific amiloride derivatives have now been e

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The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discoveryas been a subject of much puzzlement. By the 1970s, it was clear that to provide a slow depolarization, there must be a slow increase in net inward current, although it was not clear whether this came about as a consequence of the slow inactivation of an outward current (presumed to be a carried by

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The Sodium-Hydrogen Exchange System in the Heartdominance of NHE-1 in the myocardium is of some importance because pharmacological development of NHE inhibitors for cardiac therapeutics has concentrated specifically on those agents that are selective for NHE-1. These agents, as well as the earlier nonspecific amiloride derivatives have now been e

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