Titlebook: Carcinogenicity; The Design, Analysis Harold C. Grice,Joseph L. Ciminera Book 1988Latest edition Springer-Verlag New York Inc. 1988 cancer.

沙發(fā)

https://doi.org/10.1007/978-3-662-00754-9oups evaluated relative to those in unexposed controls (Bickis and Krewski, 1985a). The untreated animals are maintained on test at the same time as the treated animals and housed under the same conditions in the same laboratory. Because the concurrent controls are thus similar to the exposed animal

Ethics

https://doi.org/10.1007/978-3-662-00754-9nmental chemicals or pharmaceutical agents. Such studies are generally performed in both sexes of two rodent species, typically rats and mice, over a period of about 24 months. Chronic toxicity studies are also carried out in larger laboratory animal species, such as monkeys or dogs. The duration of

embolus

https://doi.org/10.1007/978-3-662-00754-9s presentation) were discussed. Some expressed the point of view that these inconsistencies made effective utilization of historical control data quite difficult. One way of overcoming the difficulty introduced by varied nomenclature and diagnostic criteria is to have the primary pathologist or seve

大炮

入會

Uncultured

Distribution

resistant

Akio Matsumoto,Ferenc Szidarovszkyto assess the potential carcinogenic effect of compounds. Unfortunately, decades of carcinogenicity testing have failed to provide an unequivocal set of guidelines that determines the true carcinogenic potential of a compound in laboratory animals or humans. Furthermore, there is often considerable

bypass

Narrative

Steady Flow of Slightly Viscoelastic Fluids,m of development from hyperplasia through benign to malignant tumors has not been clearly demonstrated in many tissues, and we should not presume that this always occurs. Responses referred to the demonstrated multistage development of cancer and also to the fact that no assumption of progression of