Titlebook: Cannabinoids and Sleep; Molecular, Functiona Jaime M. Monti,S. R. Pandi-Perumal,Eric Murillo-Ro Book 2021 The Editor(s) (if applicable) and

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https://doi.org/10.1007/978-3-031-34721-4support the endocannabinoid system role in the sleep-wake cycle regulation. The endocannabinoids oleamide anandamide, and 2-arachidonylglycerol promote NREM and/or REM sleep via the CB1R, thereby making this system a target to treat sleep disorders, such as insomnia.

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https://doi.org/10.1007/978-3-031-31066-9at interaction between the endocannabinoid system and the noradrenergic-serotonergic systems could account for some of the anxiolytic, antidepressant, and antinociceptive effects of cannabinoids or the disruption of attention/sleep induced by these drugs.

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Lecture Notes in Networks and Systems study in animals suggests that vaporization (which is a recommended route for medical purposes) of Cannabis with high THC and negligible CBD, promotes NREM sleep. However, it is imperative to perform new clinical studies in order to confirm if the administration of Cannabis could be a beneficial therapy for the treatment of sleep disorders.

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Sleep-Wake Neurobiology,ssion, and single-unit recordings, with emerging data using the newest technologies. Our understanding of neural circuits underlying the regulation of sleep and wakefulness is rapidly evolving, and this knowledge is critical for our field to elucidate the enigmatic function(s) of sleep.

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