Titlebook: Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology; Sadegh Babashah Book 2015 Springer International P

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Colorectal Cancer Stem Cellscribe the role of cancer stem cells in recurrence of colorectal cancer, which leads to metastasis and remains a major clinical challenge. Although the underlying biochemical and molecular events leading to recurrence of various malignancies are not fully understood, CSCs that have been shown to be r

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Pancreatic Cancer Stem Cellsng mutations in tumor suppressor genes such as . or .. The cell-of-origin of PDAC is still unknown, as both exocrine and endocrine cells can initiate tumors during chronic inflammation. Future studies investigating pancreatic stem cells and progenitor cells in more detail will help identify more pre

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Head and Neck Cancer Stem Cellsabout: (i) the recent advances in understanding the molecular mechanisms at the basis of cancer initiation and progression in Head and Neck, particularly examining the possible role of stem cells in cancer occurrence and progression in Head and Neck cancers; (ii) the identification of cellular/molec

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Leukemic and Lymphoid Stem Cellsve confirmed these findings. The publication by Bonnet et al. in 1994 offered the first prospective assessment of human cancer stem cell populations and established acute myeloid leukemia (AML) as a model system. In the intervening years, new technologies have allowed a continued reassessment of can

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Leukemic Stem Cells in Acute Lymphoblastic LeukemiaCD34. have been shown to possess leukemia-initiating capacity), but themselves evolve both in their genotype and phenotype. This conclusion was strongly supported by studies carried out in twins: basically, these studies have shown that the ALL-specific fusion events occur in utero during embryonic/

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Targeting Cancer Stem Cells and the Tumor Microenvironments. Auspicious outcomes have also been reported either by targeting pathways selectively operating in CSCs (e.g. Hedgehog, Wnt, Notch and FAK) or by using specific CSC cytotoxic agents. Other compounds are able to attenuate the unique stemness properties of CSCs by forcing cell differentiation, and t

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Cellular Plasticity, Cancer Stem Cells and Metastasis

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Implications of CXCR4/CXCL12 Interaction for Cancer Stem Cell Maintenance and Cancer Progression