Titlebook: Cancer Metastasis Through the Lymphovascular System; Stanley P. Leong,S. David Nathanson,Jonathan S. Za Textbook 2022 The Editor(s) (if ap

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Hallmarks of Cancer: Molecular Underpinningsn a set of properties and characteristics called hallmarks of cancer and enabling characteristics, respectively, that highjack the normal cellular mechanisms for their purpose. These are thought to be acquired in a stepwise fashion, in no particular order, giving cancer cells a survival advantage ov

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Unifying Concept of Genomic Changes: The Mutational Landscape of Cancersare sequenced, we discover more each day about patterns of DNA alterations, large- and small-scale chromosomal and copy number changes, epigenetic and methylome modifications, and subsequent RNA alterations among different tumor types. In this chapter we explore the global molecular alterations in d

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