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Titlebook: Calcium and Ion Channel Modulation; Alan D. Grinnell,David Armstrong,Meyer B. Jackson Book 1988 Plenum Press, New York 1988 DNA.activation

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書目名稱Calcium and Ion Channel Modulation
編輯Alan D. Grinnell,David Armstrong,Meyer B. Jackson
視頻videohttp://file.papertrans.cn/221/220800/220800.mp4
圖書封面Titlebook: Calcium and Ion Channel Modulation;  Alan D. Grinnell,David Armstrong,Meyer B. Jackson Book 1988 Plenum Press, New York 1988 DNA.activation
描述Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor- mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectivity. At the same time, biochemical techniques have revealed intricate signalling systems in- side cells, involving second messengers such as calcium, phospholipids and cyclic nucleotides, which interface with the external milieu through GTP binding proteins and regulate cell metabolism by altering protein phos- phorylation. This panorama of second messenger systems has greatly increas- ed our application for their potential role in regulating ion channel function. We now recognize that ion chan
出版日期Book 1988
關(guān)鍵詞DNA; activation; biology; cell; cell physiology; escherichia coli; growth; membrane; metabolism; neurobiology
版次1
doihttps://doi.org/10.1007/978-1-4613-0975-8
isbn_softcover978-1-4612-8273-0
isbn_ebook978-1-4613-0975-8
copyrightPlenum Press, New York 1988
The information of publication is updating

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Physiology of Multiple Calcium Channelsed in both synaptic transmission and hormone release in neuronal and secretory cells. In many excitable cells, calcium ions act as a charge carrier. Calcium ions activate the contractile machinery of both heart and skeletal muscle. In heart the slow inward Ca current is critically involved in mainta
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Expression of Presynaptic Calcium Channels in , Oocytesues there appear to be a number of different types of Ca channels, based on physiological parameters (single channel conductance, ion selectivity, voltage-dependent activation and inactivation properties) and sensitivity to pharmacological agents (especially dihydropyridines, w-conotoxin (wCgTx) and
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Control of a Light Emitting Photoprotein by Calcium Channels in a Hydrozoan Coelenterateison of the various mechanisms underlying light emission in these different animals has revealed that it is often triggered by activation of membrane channels. Consequently, many investigators have sought a better understanding of excitation-effector coupling through electrophysiological studies on
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Calcium in Photoreceptorsd by light and diffused to the plasma membrane to bind to and block the light-dependent conductance. This proposal, as well as the discovery of light-dependent G protein binding (Kühn, 1980), GTP turnover (Fung & Stryer, 1980), and phosphodiesterase activation (Wheeler & Bitensky, 1977) stimulated m
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Small Conductance Ca Activated K Channels in Mollusksed first were neurons from the marine mollusk, . . (Meech, 1976). The biophysical, pharmacological and physiological properties of that K conductance have now been studied in detail in molluscan neurons. The K conductance is not only sensitive to calcium ions but also intrinsically voltage-dependent
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Ca, Diffusion in the Cytoplasm of , Neurons: Its Relationship to Local Concentration Changesactivity of a number of membrane conductance systems. Among these are the activation of a K. channel (Meech, 1978) and the inactivation of Ca. channels (Tillotson, 1979; Eckert and Tillotson, 1981). A precise understanding of any cellular mechanism mediated by Ca. requires a definition of the Ca. co
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