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Titlebook: Calcium Entry Pathways in Non-excitable Cells; Juan A. Rosado Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive l

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發(fā)表于 2025-3-21 19:45:51 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Calcium Entry Pathways in Non-excitable Cells
編輯Juan A. Rosado
視頻videohttp://file.papertrans.cn/221/220772/220772.mp4
概述Provides an extensive overview of the mechanisms underlying calcium entry in non-excitable cells.Includes relevant background information, critical analysis of the current observations and directions
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Calcium Entry Pathways in Non-excitable Cells; Juan A. Rosado Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive l
描述Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channelsas the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomai
出版日期Book 2016
關(guān)鍵詞STIM1; Orai1; TRP channels; Calcium entry; Cellular microdomains
版次1
doihttps://doi.org/10.1007/978-3-319-26974-0
isbn_softcover978-3-319-80050-9
isbn_ebook978-3-319-26974-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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發(fā)表于 2025-3-21 21:43:16 | 只看該作者
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發(fā)表于 2025-3-22 03:07:13 | 只看該作者
The TRPCs, Orais and STIMs in ER/PM Junctionsained by Ca. influx across the plasma membrane through the Orai and TRPC channels. These Ca. influx channels form complexes at ER/PM junctions with the ER Ca. sensor STIM1, which activates the channels. The function of STIM1 is modulated by other STIM isoforms like STIM1L, STIM2 and STIM2.1/STIM2β a
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發(fā)表于 2025-3-22 09:09:34 | 只看該作者
Role of TRPC Channels in Store-Operated Calcium Entryreticulum (ER) and contributes to the control of various physiological functions in a wide variety of cell types. The transient receptor potential canonical (TRPC) channels (TRPCs 1–7), that are activated by stimuli leading to PIP. hydrolysis, were first identified as molecular components of SOCE ch
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發(fā)表于 2025-3-22 15:41:15 | 只看該作者
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發(fā)表于 2025-3-22 19:49:26 | 只看該作者
Extracellular Calcium Has Multiple Targets to Control Cell Proliferationeans by which extracellular calcium can signal to cells and regulate many cellular processes including cell proliferation, migration and invasion of tumoral cells. Many intracellular signaling pathways are sensitive to cytosolic calcium rises and conversely intracellular signaling pathways can modul
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發(fā)表于 2025-3-22 23:19:56 | 只看該作者
Regulation of Platelet Function by Orai, STIM and TRPd Ca. signals is store-operated Ca. entry (SOCE), where the Ca. sensor STIM1 and the channels of the Orai family, as well as TRPC members are the key elements. STIM1-dependent SOCE plays a major role in collagen-stimulated Ca. signaling, phosphatidylserine exposure and thrombin generation. Furthermo
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