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Titlebook: Calcium Channel Pharmacology; Stefan I. McDonough Book 2004 Kluwer Academic/Plenum Publishers, New York 2004 Calcium.Peptide.mutation.phar

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書目名稱Calcium Channel Pharmacology
編輯Stefan I. McDonough
視頻videohttp://file.papertrans.cn/221/220770/220770.mp4
圖書封面Titlebook: Calcium Channel Pharmacology;  Stefan I. McDonough Book 2004 Kluwer Academic/Plenum Publishers, New York 2004 Calcium.Peptide.mutation.phar
描述Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.
出版日期Book 2004
關(guān)鍵詞Calcium; Peptide; mutation; pharmacology; protein; receptor; research
版次1
doihttps://doi.org/10.1007/978-1-4419-9254-3
isbn_softcover978-1-4613-4860-3
isbn_ebook978-1-4419-9254-3
copyrightKluwer Academic/Plenum Publishers, New York 2004
The information of publication is updating

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Ahmed M. Ali,Bedatri Moulik,Dirk S?ffkerand α.2.3, respectively; also known as α.,α. and α.). The use of selective peptide toxins has allowed the association of Ca.2.1, 2.2 and 2.3 with P- or Q-, N-, and B-type calcium currents, respectively (Catterall, 2000; Ertel et al., 2000; Jarvis and Zamponi, 2001). These currents are found almost e
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Neue Dynamiken in der Süd-Süd-Kooperationpotent and highly selective blockers or modulators of calcium channel function, and as such are valuable pharmacological tools and potentially valuable leads in human therapeutic development. Cone shells and spiders are rich sources of such toxins, although they are also found in scorpions and insec
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https://doi.org/10.1007/978-3-322-89441-0elease, control of neuronal excitability, and gene expression (Catterall, 1998 Hofmann et al., 1999). To date, several kinds of VDCCs have been identified by electrophysiological and pharmacological means, and molecular biological studies have identified ten mammalian genes coding for the pore-formi
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https://doi.org/10.1007/978-3-663-15858-5lead to calcium channel modulation. Agonist activation of the GPCR superfamily releases a G protein heterotrimer and promotes dissociation of a G protein α subunit from a G protein βγ heterodimer. Each of these components (Gα and Gβγ) regulates calcium channel activity. Gα mediates voltage-independe
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