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Titlebook: COX-2 Blockade in Cancer Prevention and Therapy; Randall E. Harris Book 2003 Springer Science+Business Media New York 2003 Prevention of b

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發(fā)表于 2025-3-21 18:07:11 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱COX-2 Blockade in Cancer Prevention and Therapy
編輯Randall E. Harris
視頻videohttp://file.papertrans.cn/221/220538/220538.mp4
概述Includes supplementary material:
叢書名稱Cancer Drug Discovery and Development
圖書封面Titlebook: COX-2 Blockade in Cancer Prevention and Therapy; Randall E. Harris Book 2003 Springer Science+Business Media New York 2003 Prevention of b
描述The revelation that aspirin and aspirin-like compounds have notableantineo- plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op- portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma- ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly- unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings whi
出版日期Book 2003
關(guān)鍵詞Prevention of breast cancer; cancer prevention; chemoprevention; prevention; prevention and control; tumo
版次1
doihttps://doi.org/10.1007/978-1-59259-302-6
isbn_softcover978-1-61737-304-6
isbn_ebook978-1-59259-302-6Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer Science+Business Media New York 2003
The information of publication is updating

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Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Preventionents at critical points in carcinogenesis. Chemopreventive agents that can retard, block, or reverse the process of carcinogenesis, or reduction of the underlying risk factors can be applied across a continuum of the general population as preventive strategies. Understanding the mechanisms that acco
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The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung CancerSCLC) frequently overexpress cyclooxygenase-2 (COX-2), a trend particularly prominent in PAC .. This enzyme converts arachidonic acid (AA) into several metabolites, some of which have been identified as modulators of mitogenesis, angiogenesis, and apoptosis .. Accordingly, the AA cascade and COX-2 a
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Nature Management by Grazing and Cuttingin the formation of prostaglandin G. (PGG.). This COX reaction is rapidly followed by a hydroperoxidase reaction, occurring at a distinct site on the prostaglandin synthase/COX enzyme, to convert PGG. to PGH.. PGH. is the common intermediate for the synthesis of the various prostaglandins (e.g., PGE
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https://doi.org/10.1007/978-94-009-6957-5ckade in animal models of mammary carcinogenesis, summarize data from epidemiologic studies of NSAIDs and breast cancer, and present a novel working model of breast cancer development featuring aberrant induction and upregulation of . genetic expression. Extensive epidemiologic evidence and other fi
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Kant on the Foundations of ScienceSCLC) frequently overexpress cyclooxygenase-2 (COX-2), a trend particularly prominent in PAC .. This enzyme converts arachidonic acid (AA) into several metabolites, some of which have been identified as modulators of mitogenesis, angiogenesis, and apoptosis .. Accordingly, the AA cascade and COX-2 a
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