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Titlebook: CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential; R.W. Compans,M.D. Cooper,Elisabeth Suri-Payer Book 2005 The Edit

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書目名稱CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
編輯R.W. Compans,M.D. Cooper,Elisabeth Suri-Payer
視頻videohttp://file.papertrans.cn/221/220237/220237.mp4
概述Includes supplementary material:
叢書名稱Current Topics in Microbiology and Immunology
圖書封面Titlebook: CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential;  R.W. Compans,M.D. Cooper,Elisabeth Suri-Payer Book 2005 The Edit
描述.The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4.+.CD25.+. regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. ..The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under cond
出版日期Book 2005
關(guān)鍵詞Antigen; T cell; Transplant Survival; autoimmune disease; cancer; cell; cell biology; dendritic cells; disea
版次1
doihttps://doi.org/10.1007/3-540-27702-1
isbn_softcover978-3-642-06376-3
isbn_ebook978-3-540-27702-6Series ISSN 0070-217X Series E-ISSN 2196-9965
issn_series 0070-217X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
The information of publication is updating

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978-3-642-06376-3The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE
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Friedrich Schreiber,Michael Wolffsohntoimmunity. Although there is substantial data that TCR specificity is important for T. development and function, relatively little is known about the antigen specificity of naturally arising T.. Here, we will review the available evidence regarding naturally arising T. TCR specificity in the context of T. development, function, and homeostasis.
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Friedrich Schreiber,Michael Wolffsohneripheral tissue-specific tolerance is centrally established in the thymus, by epithelial stromal cells (TEC). Subsequent experiments have shown that TEC-tolerance is dominant and mediated by CD4 regulatory T cells (Treg) that are generated intrathymically by recognition of antigens expressed on TEC
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Friedrich Schreiber,Michael Wolffsohnperimental limitations inherent to the study of polyclonal suppressor T cells, and the extensive use of in vitro assays. This review article intends to outline recent advances in our understanding of the biology of suppressor T cells that have emerged from the analysis of T cell receptor (TCR) trans
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