Titlebook: Breast Cancer, a Heterogeneous Disease Entity; The Very Early Stage Zsuzsanna Kahán Book 2011 Springer Science+Business Media B.V. 2011 1.

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Large-Format Histology, a Prerequisite for Adequate Assessment of Early Breast Carcinomas,in the early stages of development in many cases. The conventional histology sampling technique applied in most laboratories today is insufficient to document this complexity in operative breast specimens. This has necessitated the special approach of using large-format histology slides, which has r

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The Molecular Evolution of Breast Cancer Precursors and Risk Indicators,he pathways of breast cancer progression. It is evident that breast cancer can be classified into distinct entities on the basis of ER expression; the type and pattern of genetic aberrations found in ER positive cancers are distinct from those found in ER negative cancers. Furthermore, the pattern a

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Sentinel Node Biopsy and Nodal Staging,rue for the smallest tumors detected through screening, which are often node-negative. Traditionally, this was assessed by the histological examination of the nodal content of the axilla removed during axillary lymph node dissection (ALND). Sentinel lymph node (SLN) biopsy (SLNB), a low morbidity su

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The Risks of Breast Radiotherapy and How to Avoid Them, even secondary cancers. Radiation pneumonitis or lung fibrosis may develop shortly after the administration of the radiotherapy. Fibrosis of the breast or the soft tissues exerts an impact on the cosmetic outcome and functioning. Life-threatening radiogenic complications such as ischaemic heart dis