Titlebook: Brain and Human Body Modeling 2020; Computational Human Sergey N. Makarov,Gregory M. Noetscher,Aapo Nummen Book‘‘‘‘‘‘‘‘ 2021 The Editor(s)

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978-3-030-45625-2The Editor(s) (if applicable) and The Author(s) 2021

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A Thermal Study of Tumor-Treating Fields for Glioblastoma Therapyly as possible, we also considered complete current shutdown whenever any transducer reached 41?°C to allow transducers and tissues’ temperature to decrease. Our results indicate an intermittent operation of Optune due to this necessary current shutdown. Localized temperature increases were seen, es

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Improving Tumor-Treating Fields with Skull Remodeling Surgery, Surgery Planning, and Treatment Evalu toward the pathology and focally enhance the field intensity. Safety and feasibility of this concept were validated in a clinical phase 1 trial (OptimalTTF-1), which also indicated promising survival benefits. This chapter describes the FE methods used in the OptimalTTF-1 trial to plan SR-surgery a

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Computational Models of Brain Stimulation with Tractography Analysislectric field and second spatial derivatives of the electrical potential along the fibre direction, which describes the activating function for homogenous axons, and investigated sensitive regions of white matter activation. Models with anisotropic white matter conductivity yielded the most distinct

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