Titlebook: Brain Organoids in Research and Therapy; Fundamental Ethical Hans-Georg Dederer,David Hamburger Book 2022 The Editor(s) (if applicable) an

CULP

Ethics Considerations Regarding Donors’ and Patients’ Consenteptable. In the context of basic research, the consent of donors whose tissues are used to derive brain organoids is of primary concern, whereas in clinical translation the consent of both allogeneic donors and patients may be relevant. In this chapter, I examine key ethics considerations related to

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PATHY

Moral Permissibility of Transplantation of Human Brain Organoids into Animalsan laboratory species. The moral permissibility of this research method is dependent on the reasons for conducting human-to-animal chimera research more generally and the oversight process that must be in place for this variant of animal research. As with any research involving highly modified anima

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Transplantation of Human Brain Organoids into Animals: The Legal Issuesnditions and pave the way towards novel therapies. At the same time, this process challenges moral intuitions and normative categories. This chapter will discuss the likely regulatory challenges resulting from the transplantation of human brain organoids into animals and address issues arising from