Titlebook: Brain Oncology Biology, diagnosis and therapy; An international mee M. Chatel,F. Darcel,J. Pecker Book 1987 Martinus Nijhoff Publishers, Do

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PATRI

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MAL

Amplification and Expression of Viral Sequences and Oncogenes in Human Brain Tumorsumors or in solid tumors (11, 16). The purpose of this study was to investigate by hybridization methods the presence of such transforming genes in the genome of brain tumors, either as introduced by viruses (Herpes simplex virus, Simian Virus 40, Adenovirus type 2) or as analog to oncogenes of retroviruses.

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BRUNT

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Immunocytochemistry and the Pathological Diagnosis of Cerebral Tumoursreas, in other tumours, the cells . marker proteins or even . markers that are inappropriate for the apparent cell of origin. The main use of immunocytochemistry in the diagnosis of cerebral tumours lies in 3 main areas:

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Chromosomal Studies in Malignant Gliomasy to a breakpoint cluster region on 22q. (2). The protein coded by the rearranged sequence resembles the product of the transforming viral sequence, v-abl. (2). Similary, the 8; 14, 2; 8, and 8; 22 translocations of Burkitt’s lymphoma move the c-myc gene to location near the genes which code for the light and heavy immunoglobulin chains (3).