Titlebook: Brain Chemistry and Mental Disease; Proceedings of a Sym Beng T. Ho,William M. McIsaac Conference proceedings 1971 Springer Science+Busines

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Comparison of the Effects of Electrical Stimulation and Iontophoretic Dopamine on Neurons of the Nig concentrations of acetylcholine (MacIntosh 1941) and the enzymes required for its synthesis (Feldberg and Vogt 1948; Hebb and Silver 1956) and catabolism (Burgen and Chipman 1951) are found in this structure. The unusually large concentration of dopamine in the caudate and other basal ganglia promp

Nomogram

Biogenic Amines and Affective Disordersnce consists of a growing number of investigations of the biogenic amines in patients suffering from depression and mania, and also of observations of the effect of manipulating brain amines on mood in patients and in normal subjects. This paper will examine some of the direct evidence for a disturb

Hyperopia

Catecholamines and Affective Illness: Studies with L-DOPA and Alpha-Methyl-Para-Tyrosinerosine (α-MPT) in the affective disorders and on the biochemical pharmacology of these agents in man and in the laboratory animal. These studies were prompted by the catecholamine hypothesis, which remains of central importance in current research in the affective disorders (Bunney and Davis 1965; S

CHANT

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Interactions between Adrenocortical Steroid Hormones, Electrolytes, and the Catecholaminesparticularly mania and depression, and each of these areas has been the focus of a great deal of investigative effort (Bunney and Davis 1965; Schildkraut 1965; Schildkraut and Kety 1967; Fawcett and Bunney 1967; Maas, Fawcett, and Dekirmenjian 1968; Williams, Katz, and Shield 1969; Coppen 1967; Gibb

Sleep-Paralysis

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Effects of Tricyclic Antidepressants on Norepinephrine Metabolism: Basic and Clinical Studiesvided important tools for investigating those neurochemical changes that may be associated with alterations in affective state in man (Schildkraut 1970). Some years ago, in clinical studies of depressed patients, we observed a decrease in the urinary excretion of 3-methoxy-4-hydroxymandelic acid (VM

CURL

Overviewdisorders. Among the differences between these two types of conditions one of the most interesting is that the affective disorders are composed of manifestations or symptoms that are much more familiar to all of us than are the manifestations of schizophrenia. It is difficult to identify with the sy

Basilar-Artery

Frequency of Genetic Polymorphism: Implications for Mental Disease,000, but this is no more than a slightly educated guess. The total amount of DNA contained in the nucleus would account for something like one hundred times that number of genes, but a large amount of the DNA, probably most of it, does not carry genetic information.

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