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Titlebook: Bortezomib in the Treatment of Multiple Myeloma; Irene M. Ghobrial,Paul G. Richardson,Kenneth C. An Book 2011 Springer Basel AG 2011 Borte

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發(fā)表于 2025-3-21 16:13:00 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Bortezomib in the Treatment of Multiple Myeloma
影響因子2023Irene M. Ghobrial,Paul G. Richardson,Kenneth C. An
視頻videohttp://file.papertrans.cn/190/189905/189905.mp4
發(fā)行地址Contemporary monograph on Bortezomib and the proteasome discovery from the lab to the clinic.A valuable source of information for researchers and clinicians from the fields of oncology and pharmacolog
學(xué)科分類Milestones in Drug Therapy
圖書封面Titlebook: Bortezomib in the Treatment of Multiple Myeloma;  Irene M. Ghobrial,Paul G. Richardson,Kenneth C. An Book 2011 Springer Basel AG 2011 Borte
影響因子Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways.This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
Pindex Book 2011
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發(fā)表于 2025-3-21 20:20:52 | 只看該作者
Preclinical Activities of Bortezomib in MM, the Bone Marrow Microenvironment and Pharmacogenomics,lls and osteoblasts in the bone marrow milieu. Importantly, combination treatment strategies, including histone deacetylase inhibitors, Akt inhibitor, lenalidomide, heat shock protein 90 inhibitors, and aurora kinase inhibitors demonstrate significant anti-MM activities both in preclinical and clini
板凳
發(fā)表于 2025-3-22 01:53:51 | 只看該作者
Bortezomib in the Upfront Treatment of Multiple Myeloma,sed combinations. In patients who are not candidates for transplant, bortezomib in combination with melphalan and prednisone has also proved to be superior to conventional therapy, with high overall and CR rates and a significantly longer time to progression and overall survival. Moreover, new strat
地板
發(fā)表于 2025-3-22 08:13:49 | 只看該作者
The Use of Bortezomib in Autologous Transplantation for Multiple Myeloma,ation of remission. Finally, modifying the conditioning regimen itself represents yet another method by which the efficacy of autologous transplant can be further enhanced. These strategies to improve the outcomes of the transplant process for patients with multiple myeloma are currently the focus o
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發(fā)表于 2025-3-22 10:53:35 | 只看該作者
Bortezomib in Relapsed and Relapsed/Refractory Multiple Myeloma,se findings have rightfully entrenched bortezomib as one of the most important parts of our chemotherapeutic armamentarium against multiple myeloma. In this chapter, we will review the role of bortezomib as a single-agent, and in combination with other chemotherapeutics, to combat myeloma in the rel
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發(fā)表于 2025-3-22 16:50:23 | 只看該作者
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發(fā)表于 2025-3-22 17:05:30 | 只看該作者
,?konomische Gestaltungsimplikationen,tors suggested other therapeutic possibilities; for example, its role in the activation of the NF-κB suggested anti-inflammatory and antineoplastic actions and led to clinical trials against various cancers. Indications of the special sensitivity of multiple myeloma were observed in Phase I trials,
8#
發(fā)表于 2025-3-23 00:44:17 | 只看該作者
Logistik im Zwischenwerksverkehrlls and osteoblasts in the bone marrow milieu. Importantly, combination treatment strategies, including histone deacetylase inhibitors, Akt inhibitor, lenalidomide, heat shock protein 90 inhibitors, and aurora kinase inhibitors demonstrate significant anti-MM activities both in preclinical and clini
9#
發(fā)表于 2025-3-23 04:49:01 | 只看該作者
Systemlogistik und Logistiksysteme,sed combinations. In patients who are not candidates for transplant, bortezomib in combination with melphalan and prednisone has also proved to be superior to conventional therapy, with high overall and CR rates and a significantly longer time to progression and overall survival. Moreover, new strat
10#
發(fā)表于 2025-3-23 07:07:39 | 只看該作者
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