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Titlebook: Bone Morphogenetic Proteins: From Local to Systemic Therapeutics; Slobodan Vukicevic,Kuber T. Sampath Book 2008 Birkh?user Basel 2008 Tiss

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發(fā)表于 2025-3-23 11:56:40 | 只看該作者
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發(fā)表于 2025-3-23 16:24:08 | 只看該作者
Systemic administration of bone morphogenetic proteins,systemically for promoting tissue regeneration and repair has existed for years. However, do we have enough information on their pharmacodynamic and pharmacokinetic properties and a reproducible production of pure preparations for clinical use, and on reproducible results of their efficacy? Do BMPs
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發(fā)表于 2025-3-24 08:06:40 | 只看該作者
https://doi.org/10.1007/978-3-030-74501-1 During the differentiation phase, the mesenchymal stem cells are transformed into osteoblasts. During the calcification phase, the osteoblasts produce matrix, generate callous and form new bone. During the maturation phase, the newly formed bone remodels into trabecular bone and increases in vascularity.
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發(fā)表于 2025-3-24 20:33:24 | 只看該作者
Bone morphogenetic protein antagonists and kidney,evel and pattern of each BMP varies dynamically during embryogenesis and kidney disease progression. BMP-7 is the most abundant BMP during kidney development [.], whereas the level of BMP-4, BMP-6 and BMP-7 are comparable in adult healthy kidneys (S. Yamada, unpublished data). BMP-2 is hardly detectable in developing and adult kidneys.
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發(fā)表于 2025-3-25 03:14:48 | 只看該作者
Book 2008rogenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), ori
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